MGI: 3609260 HomoloGene: 56886 GeneCards: CHRNA10
Targeted by Drug
• calcium channel activity
• ion channel activity
• receptor binding
• extracellular ligand-gated ion channel activity
• acetylcholine-gated cation-selective channel activity
• integral component of membrane
• postsynaptic membrane
• plasma membrane
• cell junction
• acetylcholine-gated channel complex
• positive regulation of cytosolic calcium ion concentration
• synaptic transmission, cholinergic
• ion transport
• detection of mechanical stimulus involved in sensory perception of sound
• regulation of cell proliferation
• calcium ion transmembrane transport
• inner ear morphogenesis
• calcium ion transport
• regulation of postsynaptic membrane potential
• excitatory postsynaptic potential
Sources:Amigo / QuickGO
Chr 11: 3.67 – 3.67 Mb
Chr 7: 102.11 – 102.12 Mb
Neuronal acetylcholine receptor subunit alpha-10 also known as cholinergic receptor nicotinic alpha 10 is a protein that in humans is encoded by the CHRNA10 gene. The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).
This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system. Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.
^ “Drugs that physically interact with Cholinergic receptor nicotinic alpha 10 subunit view/edit references on wikidata”.
^ “Human PubMed Reference:”.
^ “Mouse PubMed Reference:”.
^ Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). “Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)”. Genomics.