set1

2017-02-03

CHRNA10

CHRNA10

Identifiers

Aliases
CHRNA10

External IDs
MGI: 3609260 HomoloGene: 56886 GeneCards: CHRNA10

Targeted by Drug

muscarine[1]

Gene ontology

Molecular function
• calcium channel activity
• ion channel activity
• receptor binding
• extracellular ligand-gated ion channel activity
• acetylcholine-gated cation-selective channel activity

Cellular component
• integral component of membrane
• perikaryon
• postsynaptic membrane
• membrane
• plasma membrane
• synapse
• axon
• cell junction
• acetylcholine-gated channel complex

Biological process
• positive regulation of cytosolic calcium ion concentration
• synaptic transmission, cholinergic
• ion transport
• detection of mechanical stimulus involved in sensory perception of sound
• regulation of cell proliferation
• calcium ion transmembrane transport
• inner ear morphogenesis
• transport
• calcium ion transport
• regulation of postsynaptic membrane potential
• excitatory postsynaptic potential

Sources:Amigo / QuickGO

Orthologs

Species
Human
Mouse

Entrez

57053

504186

Ensembl

ENSG00000129749

ENSMUSG00000066279

UniProt

Q9GZZ6

n/a

RefSeq (mRNA)

NM_001303034
NM_001303035
NM_020402

NM_001081424

RefSeq (protein)

NP_001289963
NP_001289964
NP_065135

n/a

Location (UCSC)
Chr 11: 3.67 – 3.67 Mb
Chr 7: 102.11 – 102.12 Mb

PubMed search
[2]
[3]

Wikidata

View/Edit Human
View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-10 also known as cholinergic receptor nicotinic alpha 10 is a protein that in humans is encoded by the CHRNA10 gene.[4] The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).
This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[5] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[6]
References[edit]

^ “Drugs that physically interact with Cholinergic receptor nicotinic alpha 10 subunit view/edit references on wikidata”. 
^ “Human PubMed Reference:”. 
^ “Mouse PubMed Reference:”. 
^ Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). “Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)”. Genomics.